Pauline Dorthea Wyman Wilson was born on September 10, 1905 in Minnesota to Paul Wyman and Lillian Kennedy Wyman. Paul Wyman died a few months before Pauline's birth, and Pauline and her brother Donald were raised by Lillian in Pennsylvania. Pauline graduated from William Penn High School for Girls, Philadelphia in 1924, and Vassar College in 1928 where she was elected to Phi Beta Kappa. She believed strongly in women's education.
Following her graduation from Vassar, Pauline Wyman Wilson worked as a substitute teacher in the Philadelphia School District for one year. She then pursued graduate studies at the University of Pennsylvania, Cornell University, the University of Wisconsin, and the University of Chicago. She earned a master's degree from the University of Pennsylvania, Philadelphia in 1929.
Pauline Wyman Wilson was Assistant Professor of Biology and Chemistry at Western Maryland College until 1936, then joined Northwestern University's personnel administration where she presided over the women's division of counselors. She left her job at Northwestern University when she married Edward Foss Wilson in 1940.
Pauline was a member of the Child Health Center Board at the Washington, D.C. Children's Hospital (now Children's National), and helped to organize several primary care clinics in Washington, D.C. She was also an active member of the Chevy Chase Club, and was a fundraiser for the construction of the John F. Kennedy Center for the Performing Arts.
Pauline Wyman Wilson died of Alzheimer's disease on October 1, 1985.