| D'Alton, John. Collection |
| Danner, Margaret. Papers |
| Danos, Michael. Papers |
| Darrow, Clarence. Papers |
| Darwin Centennial Celebration. Records |
| Darwin, Charles. Scientific Communication |
| Davis, Allison. Papers |
| Davis, Fred Merrill. Central Power Station Equipment for Telephone Exchanges |
| Davis, Jefferson, Trial Papers. MS 979 |
| Day, Warren J. Papers |
| De Forest, Lee. Papers |
| De La Garde, Philip Chilwell. Three Letters |
| De Lee, Joseph B. Notes on Obstetrics |
| De Morgan, Augustus. Lectures on Algebra |
| De Roover, Florence Edler. Papers |
| De oculo tractatio |
| Debs, Eugene V., Walls and Bars. Manuscript |
| Debus, Allen G. Papers |
| Deems, Barrett. Papers |
| Deland, Margaret Wade. Three Letters to Dr. Hugo Erichsen |
| Delaurier, E.T. Aérien et moteur à feu : description et dessins. Scrapbook |
| Dennis, Helen I. Collection on Theosophical Society |
| Depense de la Bouche du Roy Louis XIV |
| Der Monat. Records |
| Dewey, Donald J. Collection of Frank Knight |
| Dewey, John. Collection |
| Dewey, Richard Smith. Papers |
| Dickens, Charles. Collection |
| Dieckmann, Annetta M., Papers |
| Dilworth, Hiram Powers. Papers |
| Dimock, Edward C. Papers |
| Dimsdale, Joseph. Collection |
| Diodorus, Siculus, Bibliotheca historiarum, libri I-VI. Manuscript (Ms 241) |
| Diodorus, Siculus, Bibliotheca historica. Manuscript (Ms 14) |
| Diogenes Laertius, De vita et moribus philosophorum. Manuscript (Ms 15) |
| Director, Aaron. Papers |
| Dixson, Zella Allen. Papers |
| Documentary Film Group. Records |
| Dodd, William E. Papers |
| Dopierala, Walter C. Comic Book Collection |
| Douglas Family. Collection |
| Douglas, Paul H. Papers |
| Douglas, Stephen A. Papers |
| Drew, Helen L.. Correspondence |
| DuBois, Cora. Papers |
| Duckworth, Sir John Thomas. Papers |
| Duncombe, Ariel. The Practice of Medicine, |
| Dunham. Allison. Papers |
| Dunn Family. Collection |
| Durrett, Reuben T. Collection. Boggs Family Papers |
| Durrett, Reuben T. Collection. Boone Family Papers |
| Durrett, Reuben T. Collection. Broadsides, Broadsheets, Pamphlets, and Leaflets |
| Durrett, Reuben T. Collection. Christopher Columbus Graham Papers |
| Durrett, Reuben T. Collection. Edmund Lyne Estate Records |
| Durrett, Reuben T. Collection. George Nicholas Papers |
| Durrett, Reuben T. Collection. George Rogers Clark Papers |
| Durrett, Reuben T. Collection. Government Records |
| Durrett, Reuben T. Collection. James Wilkinson Papers |
| Durrett, Reuben T. Collection. Joel Tanner Hart Papers |
| Durrett, Reuben T. Collection. Joshua Lacy Wilson Papers |
| Durrett, Reuben T. Collection. Lewis Family Papers |
| Durrett, Reuben T. Collection. Louisville, Kentucky Board of Trustees Records |
| Durrett, Reuben T. Collection. Mann Butler Papers |
| Durrett, Reuben T. Collection. Michael Walsh Cluskey Papers |
| Durrett, Reuben T. Collection. Miscellaneous Manuscripts and Codices |
| Durrett, Reuben T. Collection. Portraits, Illustrations, and Cartographic Material |
| Durrett, Reuben T. Collection. Richard H. Collins Papers |
| Durrett, Reuben T. Collection. Richard Jouett Meneffee Collection on Matthew Harris Jouett |
| Durrett, Reuben T. Collection. Shelby Family Papers |
| Durrett, Reuben T. Collection. William and George Croghan Papers |
| Durrett, Reuben T. Personal Papers |
| Dyke, Andrew Lee. Collection |